Efavirenz and Bupropion Interaction
Drug interaction information between Efavirenz and Bupropion.
Efavirenz and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Efavirenz and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The HIV medicine lowers the concentration of the antidepressant in your blood, which might make it less effective.
FDA Label Information
Antidepressant: Bupropion Sertraline ↓bupropion* ↓ sertraline * Increases in bupropion dosage should be guided by clinical response. Bupropion dose should not exceed the maximum recommended dose.
Efavirenz Also Interacts With
- Clarithromycin moderate
- Sofosbuvir/Velpatasvir moderate
- Posaconazole moderate
- Atorvastatin minor
- Sertraline minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Efavirenz/Emtricitabine/Tenofovir + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Efavirenz's 32. In the minor band specifically: Efavirenz has 29 (also Atorvastatin, Sertraline, Simvastatin, Famotidine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Efavirenz/Emtricitabine/Tenofovir and Bupropion?
The HIV medicine lowers the concentration of the antidepressant in your blood, which might make it less effective.
Bupropion carries more major-labeled pairs than Efavirenz
SPL source-record counts only. This page's band is minor · classes on file: Efavirenz (NNRTI / NRTI Combination); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Efavirenz's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 29 minor · 32 total
- Other minor peers for Efavirenz
- Atorvastatin
- Sertraline
- Simvastatin
- Famotidine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.