Efavirenz and Sertraline Interaction
Drug interaction information between Efavirenz and Sertraline.
Efavirenz and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Efavirenz and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can lower the amount of the antidepressant in your body.
FDA Label Information
Antidepressant: Bupropion Sertraline ↓bupropion* ↓ sertraline * Increases in bupropion dosage should be guided by clinical response. Increases in sertraline dosage should be guided by clinical response.
Efavirenz Also Interacts With
- Clarithromycin moderate
- Sofosbuvir/Velpatasvir moderate
- Posaconazole moderate
- Atorvastatin minor
- Bupropion minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Efavirenz/Emtricitabine/Tenofovir + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Efavirenz's 32. In the minor band specifically: Efavirenz has 29 (also Atorvastatin, Bupropion, Simvastatin, Famotidine); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Efavirenz/Emtricitabine/Tenofovir and Sertraline?
Taking these drugs together can lower the amount of the antidepressant in your body.
Sertraline carries more major-labeled pairs than Efavirenz
SPL source-record counts only. This page's band is minor · classes on file: Efavirenz (NNRTI / NRTI Combination); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Efavirenz's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 29 minor · 32 total
- Other minor peers for Efavirenz
- Atorvastatin
- Bupropion
- Simvastatin
- Famotidine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.