Efavirenz and Clarithromycin Interaction
Drug interaction information between Efavirenz and Clarithromycin.
Efavirenz and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Efavirenz and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can change how the antibiotic is processed and may cause a dangerous heart rhythm problem.
FDA Label Information
Anti-infective: Clarithromycin ↓ clarithromycin * ↑ 14-OH metabolite * Consider alternatives to macrolide antibiotics because of the risk of QT interval prolongation.
Efavirenz Also Interacts With
- Sofosbuvir/Velpatasvir moderate
- Posaconazole moderate
- Atorvastatin minor
- Sertraline minor
- Bupropion minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Efavirenz/Emtricitabine/Tenofovir + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Efavirenz's 32. In the moderate band specifically: Efavirenz has 3 (also Sofosbuvir/Velpatasvir, Posaconazole); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Efavirenz/Emtricitabine/Tenofovir and Clarithromycin?
This combination can change how the antibiotic is processed and may cause a dangerous heart rhythm problem.
Clarithromycin carries more major-labeled pairs than Efavirenz
SPL source-record counts only. This page's band is moderate · classes on file: Efavirenz (NNRTI / NRTI Combination); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Efavirenz's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 29 minor · 32 total
- Other moderate peers for Efavirenz
- Sofosbuvir/Velpatasvir
- Posaconazole
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.