Efavirenz and Simvastatin Interaction
Drug interaction information between Efavirenz and Simvastatin.
Efavirenz and Simvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Efavirenz and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination causes the cholesterol medicine to be cleared from your body faster than usual.
FDA Label Information
HMG-CoA reductase inhibitors: Atorvastatin Pravastatin Simvastatin ↓ atorvastatin * ↓ pravastatin * ↓ simvastatin * Plasma concentrations of atorvastatin, pravastatin, and simvastatin decreased.
Efavirenz Also Interacts With
- Clarithromycin moderate
- Sofosbuvir/Velpatasvir moderate
- Posaconazole moderate
- Atorvastatin minor
- Sertraline minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Efavirenz/Emtricitabine/Tenofovir + Simvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Efavirenz's 32. In the minor band specifically: Efavirenz has 29 (also Atorvastatin, Sertraline, Bupropion, Famotidine); Simvastatin has 21 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Efavirenz/Emtricitabine/Tenofovir and Simvastatin?
This combination causes the cholesterol medicine to be cleared from your body faster than usual.
Simvastatin carries more major-labeled pairs than Efavirenz
SPL source-record counts only. This page's band is minor · classes on file: Efavirenz (NNRTI / NRTI Combination); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Efavirenz's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 29 minor · 32 total
- Other minor peers for Efavirenz
- Atorvastatin
- Sertraline
- Bupropion
- Famotidine
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.