Efavirenz and Atorvastatin Interaction
Drug interaction information between Efavirenz and Atorvastatin.
Efavirenz and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Efavirenz and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The HIV medicine makes your body process the cholesterol drug more quickly, lowering its level in your blood.
FDA Label Information
HMG-CoA reductase inhibitors: Atorvastatin Pravastatin Simvastatin ↓ atorvastatin * ↓ pravastatin * ↓ simvastatin * Plasma concentrations of atorvastatin, pravastatin, and simvastatin decreased.
Efavirenz Also Interacts With
- Clarithromycin moderate
- Sofosbuvir/Velpatasvir moderate
- Posaconazole moderate
- Sertraline minor
- Bupropion minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Efavirenz/Emtricitabine/Tenofovir + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Efavirenz's 32. In the minor band specifically: Efavirenz has 29 (also Sertraline, Bupropion, Simvastatin, Famotidine); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Efavirenz/Emtricitabine/Tenofovir and Atorvastatin?
The HIV medicine makes your body process the cholesterol drug more quickly, lowering its level in your blood.
Atorvastatin carries more major-labeled pairs than Efavirenz
SPL source-record counts only. This page's band is minor · classes on file: Efavirenz (NNRTI / NRTI Combination); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Efavirenz's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 29 minor · 32 total
- Other minor peers for Efavirenz
- Sertraline
- Bupropion
- Simvastatin
- Famotidine
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.