Efavirenz and Sofosbuvir/Velpatasvir Interaction
Drug interaction information between Efavirenz and Sofosbuvir/Velpatasvir.
Efavirenz and Sofosbuvir/Velpatasvir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Efavirenz and Sofosbuvir/Velpatasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
One medicine lowers the amount of the hepatitis C drug in your body, which can stop it from working correctly.
FDA Label Information
Velpatasvir/ Sofosbuvir ↓ velpatasvir Co-administration of efavirenz and sofosbuvir/velpatasvir is not recommended because it may result in loss of therapeutic effect of sofosbuvir/velpatasvir Velpatasvir /Sofosbuvir/Voxilaprevir ↓ velpatasvir ↓ voxilaprevir Co-administration of efavirenz and sofosbuvir/velpatasvir/voxilaprevir is not recommended because it may result in loss of therapeutic effect of sofosbuvir/velpatasvir/voxilaprevir.
Efavirenz Also Interacts With
- Clarithromycin moderate
- Posaconazole moderate
- Atorvastatin minor
- Sertraline minor
- Bupropion minor
Sofosbuvir/Velpatasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Pravastatin moderate
- Methotrexate moderate
Frequently Asked Questions
What SPL severity band is on file for Efavirenz/Emtricitabine/Tenofovir + Sofosbuvir/Velpatasvir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sofosbuvir/Velpatasvir has 33 labeled pairs on file vs Efavirenz's 32. In the moderate band specifically: Efavirenz has 3 (also Clarithromycin, Posaconazole); Sofosbuvir/Velpatasvir has 10 (also Pravastatin, Methotrexate, Cyclosporine, Carbamazepine).
What mechanism field is on file for Efavirenz/Emtricitabine/Tenofovir and Sofosbuvir/Velpatasvir?
One medicine lowers the amount of the hepatitis C drug in your body, which can stop it from working correctly.
Sofosbuvir/Velpatasvir carries more major-labeled pairs than Efavirenz
SPL source-record counts only. This page's band is moderate · classes on file: Efavirenz (NNRTI / NRTI Combination); Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)).
Sofosbuvir/Velpatasvir has 3 major-labeled pairs vs Efavirenz's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 29 minor · 32 total
- Other moderate peers for Efavirenz
- Clarithromycin
- Posaconazole
3 major · 10 moderate · 20 minor · 33 total
- Other moderate peers for Sofosbuvir/Velpatasvir
- Pravastatin
- Methotrexate
- Cyclosporine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.