Perindopril and Cyclosporine Interaction
Drug interaction information between Perindopril and Cyclosporine.
Perindopril and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Perindopril and Cyclosporine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs can both increase the amount of potassium in your blood to unsafe levels.
What To Do
Monitor your blood work closely as directed by your doctor. Report any muscle weakness or heart rhythm changes immediately.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Amiloride moderate
- Indomethacin moderate
- Heparin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
Can I take Perindopril and Cyclosporine together?
This is a moderate interaction. Monitor your blood work closely as directed by your doctor. Report any muscle weakness or heart rhythm changes immediately.
How serious is the interaction between Perindopril and Cyclosporine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Perindopril and Cyclosporine interact?
These drugs can both increase the amount of potassium in your blood to unsafe levels.
Understanding the Perindopril and Cyclosporine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Perindopril belongs to the ACE Inhibitor class and Cyclosporine belongs to the Calcineurin Inhibitor (Immunosuppressant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs can both increase the amount of potassium in your blood to unsafe levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Perindopril has 9 total documented interactions on file in this dataset, and Cyclosporine has 89. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor your blood work closely as directed by your doctor. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Perindopril or Cyclosporine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.