Perindopril and Cyclosporine Interaction
Drug interaction information between Perindopril and Cyclosporine.
Perindopril and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Perindopril and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can both increase the amount of potassium in your blood to unsafe levels.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Amiloride moderate
- Indomethacin moderate
- Heparin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Perindopril's 9. In the moderate band specifically: Perindopril has 5 (also Spironolactone, Amiloride, Indomethacin, Heparin); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Perindopril and Cyclosporine?
These drugs can both increase the amount of potassium in your blood to unsafe levels.
Cyclosporine carries more major-labeled pairs than Perindopril
SPL source-record counts only. This page's band is moderate · classes on file: Perindopril (ACE Inhibitor); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Perindopril's 1. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Perindopril
- Spironolactone
- Amiloride
- Indomethacin
- Heparin
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.