Perindopril and Heparin Interaction
Drug interaction information between Perindopril and Heparin.
Perindopril and Heparin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Perindopril and Heparin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can cause your body to hold onto too much potassium. When taken together, your potassium levels might rise to an unsafe level.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Amiloride moderate
- Indomethacin moderate
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Dipyridamole moderate
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Heparin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Perindopril's 9. In the moderate band specifically: Perindopril has 5 (also Spironolactone, Cyclosporine, Amiloride, Indomethacin); Heparin has 10 (also Ibuprofen, Celecoxib, Hydroxychloroquine, Indomethacin).
What mechanism field is on file for Perindopril and Heparin?
Both of these drugs can cause your body to hold onto too much potassium. When taken together, your potassium levels might rise to an unsafe level.
Perindopril carries more major-labeled pairs than Heparin
SPL source-record counts only. This page's band is moderate · classes on file: Perindopril (ACE Inhibitor); Heparin (Unfractionated Heparin).
Perindopril has 1 major-labeled pair vs Heparin's 0. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Perindopril
- Spironolactone
- Cyclosporine
- Amiloride
- Indomethacin
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Hydroxychloroquine
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.