What the FDA labels say about taking them together
Heparin and perindopril
Perindopril's FDA label of March 13, 2024 names heparin in its drug interactions section; the heparin labels PlainMeds reads (4) do not name perindopril. The perindopril label: “Use of potassium-sparing diuretics, potassium supplements or other drugs capable of increasing serum potassium can increase the risk of hyperkalemia.”
Check it at the source: the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC); the perindopril FDA label on DailyMed (effective March 13, 2024, Aurobindo Pharma Limited).
What does the heparin label say about perindopril?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name perindopril in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
What does the perindopril label say about heparin?
Perindopril label, drug interactionsUse of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Source: FDA drug label (Perindopril Erbumine), Aurobindo Pharma Limited, effective March 13, 2024 (SPL set 87768fbf-7c63-47da-8925-0316f343d6ef), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Heparin | Perindopril | |
|---|---|---|
| Labeled for | Blood clots (DVT and PE), Atrial fibrillation | High blood pressure, Heart attack and coronary artery disease |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.18 per mL 5,000 unit/mL vial | $0.495 per tablet 4 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once