Cyclosporine and Simvastatin Interaction
Drug interaction information between Cyclosporine and Simvastatin.
Cyclosporine and Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cyclosporine and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine prevents your body from processing simvastatin correctly, which can cause a dangerous amount of the drug to build up. This significantly increases the risk of severe muscle breakdown.
FDA Label Information
Cyclosporine, Danazol, or Gemfibrozil Clinical Impact: The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin. Intervention: Concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin is contraindicated [see Contraindications ( 4 )].
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Aliskiren moderate
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Amiodarone major
- Dronedarone major
- Ranolazine major
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Simvastatin's 41. In the major band specifically: Cyclosporine has 5 (also Clarithromycin, Ezetimibe, Ezetimibe/Simvastatin, Pitavastatin); Simvastatin has 11 (also Diltiazem, Verapamil, Amiodarone, Dronedarone).
What mechanism field is on file for Cyclosporine and Simvastatin?
Cyclosporine prevents your body from processing simvastatin correctly, which can cause a dangerous amount of the drug to build up. This significantly increases the risk of severe muscle breakdown.
Simvastatin carries more major-labeled pairs than Cyclosporine
SPL source-record counts only. This page's band is major · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Cyclosporine's 5.
5 major · 24 moderate · 60 minor · 89 total
- Other major peers for Cyclosporine
- Clarithromycin
- Ezetimibe
- Ezetimibe/Simvastatin
- Pitavastatin
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Amiodarone
- Dronedarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.