Cyclosporine and Amlodipine/Valsartan Interaction
Drug interaction information between Cyclosporine and Amlodipine/Valsartan.
Cyclosporine and Amlodipine/Valsartan have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cyclosporine and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine can slow down how your body breaks down cyclosporine, which raises the amount of the drug in your system. This combination can also increase your risk of high uric acid and gout.
FDA Label Information
Immunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when coadministered. Frequent monitoring of trough blood levels of cyclosporine and tacrolimus is recommended and adjust the dose when appropriate [see Clinical Pharmacology (12.3)] . Cyclosporine: Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and gout-type complications.
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Lithium moderate
- Amlodipine minor
- Hydrochlorothiazide minor
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Amlodipine/Valsartan's 14. In the moderate band specifically: Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Atorvastatin); Amlodipine/Valsartan has 2 (also Lithium).
What mechanism field is on file for Cyclosporine and Amlodipine/Valsartan?
Amlodipine can slow down how your body breaks down cyclosporine, which raises the amount of the drug in your system. This combination can also increase your risk of high uric acid and gout.
Cyclosporine carries more major-labeled pairs than Amlodipine/Valsartan
SPL source-record counts only. This page's band is moderate · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Amlodipine/Valsartan (CCB / ARB Combination).
Cyclosporine has 5 major-labeled pairs vs Amlodipine/Valsartan's 2. This page itself is in the moderate band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Atorvastatin
2 major · 2 moderate · 10 minor · 14 total
- Other moderate peers for Amlodipine/Valsartan
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.