Perindopril and Spironolactone Interaction
Drug interaction information between Perindopril and Spironolactone.
Perindopril and Spironolactone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Perindopril and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can cause your body to hold onto extra potassium instead of getting rid of it.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Perindopril Also Interacts With
- Aliskiren major
- Cyclosporine moderate
- Amiloride moderate
- Indomethacin moderate
- Heparin moderate
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Spironolactone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Perindopril's 9. In the moderate band specifically: Perindopril has 5 (also Cyclosporine, Amiloride, Indomethacin, Heparin); Spironolactone has 9 (also Lithium, Trimethoprim, Heparin, Amlodipine/Benazepril).
What mechanism field is on file for Perindopril and Spironolactone?
Both of these medicines can cause your body to hold onto extra potassium instead of getting rid of it.
Perindopril carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is moderate · classes on file: Perindopril (ACE Inhibitor); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
Perindopril has 1 major-labeled pair vs Spironolactone's 0. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Perindopril
- Cyclosporine
- Amiloride
- Indomethacin
- Heparin
0 major · 9 moderate · 14 minor · 23 total
- Other moderate peers for Spironolactone
- Lithium
- Trimethoprim
- Heparin
- Amlodipine/Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.