Perindopril and Spironolactone Interaction
Drug interaction information between Perindopril and Spironolactone.
Perindopril and Spironolactone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Perindopril and Spironolactone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medicines can cause your body to hold onto extra potassium instead of getting rid of it.
What To Do
Your doctor should check your blood potassium levels often to make sure they stay in a safe range.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Perindopril Also Interacts With
- Aliskiren major
- Cyclosporine moderate
- Amiloride moderate
- Indomethacin moderate
- Heparin moderate
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
Can I take Perindopril and Spironolactone together?
This is a moderate interaction. Your doctor should check your blood potassium levels often to make sure they stay in a safe range.
How serious is the interaction between Perindopril and Spironolactone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Perindopril and Spironolactone interact?
Both of these medicines can cause your body to hold onto extra potassium instead of getting rid of it.
Understanding the Perindopril and Spironolactone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Perindopril belongs to the ACE Inhibitor class and Spironolactone belongs to the Potassium-Sparing Diuretic / Aldosterone Antagonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medicines can cause your body to hold onto extra potassium instead of getting rid of it. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Perindopril has 9 total documented interactions on file in this dataset, and Spironolactone has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should check your blood potassium levels often to make sure they stay in a safe range. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Perindopril or Spironolactone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.