Cyclosporine and Allopurinol Interaction
Drug interaction information between Cyclosporine and Allopurinol.
Cyclosporine and Allopurinol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cyclosporine and Allopurinol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Allopurinol slows down how your body gets rid of cyclosporine, leading to higher levels of the drug in your system.
FDA Label Information
Cyclosporine Clinical Impact Concomitant use of allopurinol increases cyclosporine concentrations, which may increase the risk of adverse reactions. Intervention Increase frequency of monitoring cyclosporine concentrations as reflected in its prescribing information and modify the dosage of cyclosporine as appropriate when used concomitantly with allopurinol tablets.
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Allopurinol Also Interacts With
- Pegloticase major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Warfarin minor
- Theophylline minor
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Allopurinol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Allopurinol's 10. In the moderate band specifically: Cyclosporine has 24 (also Aliskiren, Amiloride, Amlodipine/Valsartan, Atorvastatin); Allopurinol has 3 (also Amoxicillin, Amoxicillin/Clavulanate).
What mechanism field is on file for Cyclosporine and Allopurinol?
Allopurinol slows down how your body gets rid of cyclosporine, leading to higher levels of the drug in your system.
Cyclosporine carries more major-labeled pairs than Allopurinol
SPL source-record counts only. This page's band is moderate · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Allopurinol (Xanthine Oxidase Inhibitor).
Cyclosporine has 5 major-labeled pairs vs Allopurinol's 1. This page itself is in the moderate band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Amiloride
- Amlodipine/Valsartan
- Atorvastatin
1 major · 3 moderate · 6 minor · 10 total
- Other moderate peers for Allopurinol
- Amoxicillin
- Amoxicillin/Clavulanate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.