Perindopril and Indomethacin Interaction
Drug interaction information between Perindopril and Indomethacin.
Perindopril and Indomethacin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Perindopril and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these medicines at the same time can cause your blood potassium levels to rise too high.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Amiloride moderate
- Heparin moderate
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Warfarin moderate
- Meloxicam minor
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Indomethacin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Perindopril's 9. In the moderate band specifically: Perindopril has 5 (also Spironolactone, Cyclosporine, Amiloride, Heparin); Indomethacin has 5 (also Methotrexate, Diflunisal, Heparin, Warfarin).
What mechanism field is on file for Perindopril and Indomethacin?
Using these medicines at the same time can cause your blood potassium levels to rise too high.
Perindopril carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is moderate · classes on file: Perindopril (ACE Inhibitor); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Perindopril has 1 major-labeled pair vs Indomethacin's 0. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Perindopril
- Spironolactone
- Cyclosporine
- Amiloride
- Heparin
0 major · 5 moderate · 30 minor · 35 total
- Other moderate peers for Indomethacin
- Methotrexate
- Diflunisal
- Heparin
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.