Cyclosporine and Amiloride Interaction
Drug interaction information between Cyclosporine and Amiloride.
Cyclosporine and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cyclosporine and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause potassium levels in your blood to rise. Taking them together increases the risk of having too much potassium, which can be dangerous.
FDA Label Information
Drug Interactions When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased.
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Amiloride Also Interacts With
- Potassium Chloride major
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
- Perindopril moderate
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Amiloride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Amiloride's 19. In the moderate band specifically: Cyclosporine has 24 (also Aliskiren, Allopurinol, Amlodipine/Valsartan, Atorvastatin); Amiloride has 7 (also Lithium, Amlodipine/Benazepril, Benazepril, Perindopril).
What mechanism field is on file for Cyclosporine and Amiloride?
Both of these medications can cause potassium levels in your blood to rise. Taking them together increases the risk of having too much potassium, which can be dangerous.
Cyclosporine carries more major-labeled pairs than Amiloride
SPL source-record counts only. This page's band is moderate · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Amiloride (Potassium-Sparing Diuretic).
Cyclosporine has 5 major-labeled pairs vs Amiloride's 1. This page itself is in the moderate band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amlodipine/Valsartan
- Atorvastatin
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Lithium
- Amlodipine/Benazepril
- Benazepril
- Perindopril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.