Prescription medication · ACE Inhibitor
perindopril
Also sold as Aceon. Perindopril treats high blood pressure (hypertension).
Data updated 2026-05-15
- 9
- InteractionsFew interactions
- $0.50
- Generic price (NADAC)
perindopril (Aceon) is a prescription ACE Inhibitor. Perindopril treats high blood pressure (hypertension).
Perindopril (Aceon) is a drug that lowers blood pressure. It can also help reduce the risk of heart problems in people with stable coronary artery disease.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.50/unit
Generic Available
Yes (1 manufacturer)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Perindopril treats high blood pressure (hypertension).
Common side effects
Cough, Dizziness, Back pain
Key warnings
If you become pregnant, stop taking perindopril right away.
The sections below are summarized in plain English from perindopril's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Perindopril belongs to a class of drugs called ACE inhibitors. It works by relaxing your blood vessels, which lowers blood pressure. This makes it easier for your heart to pump blood.
Serious Warnings
If you become pregnant, stop taking perindopril right away. This medicine can cause serious harm or death to an unborn baby.
Known Drug Interactions
7.8 Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with perindopril erbumine in patients with diabetes. Avoid use of aliskiren with perindopril erbumine in patients with renal impairment (GFR <60 mL/min).
Mechanism: Using these two drugs together puts too much stress on the system that controls blood pressure and kidney function. This can cause your blood pressure to drop too low and may lead to sudden kidney failure.
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Mechanism: Both of these medicines can cause your body to hold onto extra potassium instead of getting rid of it.
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Mechanism: These drugs can both increase the amount of potassium in your blood to unsafe levels.
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Mechanism: Both drugs prevent your kidneys from removing potassium, which can lead to a buildup in your system.
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Mechanism: Using these medicines at the same time can cause your blood potassium levels to rise too high.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take perindopril if I have diabetes?
What should I do if I experience swelling of my face, lips, or tongue?
Can I take perindopril with other medications?
Will perindopril cure my high blood pressure?
Can I drink alcohol while taking perindopril?
What if I am over 70 years old?
Can I take perindopril with a neprilysin inhibitor?
What are the signs of low blood pressure?
What should I do if I think I have taken too much perindopril?
Does perindopril interact with gold injections?
What are the common side effects of perindopril?
Does perindopril interact with other medications?
What drug class is perindopril?
What pregnancy or breastfeeding source fields are listed for perindopril?
Related Medications in ACE Inhibitor
Other drugs grouped near perindopril - same-class peers and common alternatives.
acebutolol
Sectral
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats.
Compare with perindopril →
aliskiren
Tekturna
Tekturna is a medicine used to treat high blood pressure.
Compare with perindopril →
amiloride
Midamor
Amiloride is a water pill that helps your body hold onto potassium.
Compare with perindopril →
amlodipine
Norvasc
Amlodipine (Norvasc) is a drug that lowers blood pressure and treats chest pain.
Compare with perindopril →
amlodipine/benazepril
Lotrel
Lotrel is a combination medicine that contains amlodipine and benazepril.
Compare with perindopril →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for perindopril
The FDA label for perindopril (sold under brand names such as Aceon) classifies it as a prescription-only medication in the ACE Inhibitor class. Perindopril treats high blood pressure (hypertension). Official labeling lists 3 commonly reported side effects, including Cough, Dizziness, Back pain.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 9 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.50.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: March 13, 2024
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages