Cyclosporine and Ezetimibe Interaction
Drug interaction information between Cyclosporine and Ezetimibe.
Cyclosporine and Ezetimibe have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cyclosporine and Ezetimibe. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these medicines together greatly increases the risk of serious muscle breakdown and damage.
What To Do
Do not use these medications together.
FDA Label Information
Cyclosporine, Danazol, or Gemfibrozil Clinical Impact: The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin. Intervention: Concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin is contraindicated [see Contraindications ( 4 )].
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
- Aliskiren moderate
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
Can I take Cyclosporine and Ezetimibe together?
This is a major interaction. Do not use these medications together.
How serious is the interaction between Cyclosporine and Ezetimibe?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Cyclosporine and Ezetimibe interact?
Taking these medicines together greatly increases the risk of serious muscle breakdown and damage.
Understanding the Cyclosporine and Ezetimibe Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Cyclosporine belongs to the Calcineurin Inhibitor (Immunosuppressant) class and Ezetimibe belongs to the Cholesterol Absorption Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these medicines together greatly increases the risk of serious muscle breakdown and damage. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Cyclosporine has 89 total documented interactions on file in this dataset, and Ezetimibe has 25. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not use these medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Cyclosporine or Ezetimibe based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.