Cyclosporine and Ezetimibe Interaction
Drug interaction information between Cyclosporine and Ezetimibe.
Cyclosporine and Ezetimibe have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cyclosporine and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together greatly increases the risk of serious muscle breakdown and damage.
FDA Label Information
Cyclosporine, Danazol, or Gemfibrozil Clinical Impact: The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin. Intervention: Concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin is contraindicated [see Contraindications ( 4 )].
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
- Aliskiren moderate
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Ezetimibe?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Ezetimibe's 25. In the major band specifically: Cyclosporine has 5 (also Clarithromycin, Ezetimibe/Simvastatin, Pitavastatin, Simvastatin); Ezetimibe has 8 (also Amlodipine, Diltiazem, Verapamil, Amiodarone).
What mechanism field is on file for Cyclosporine and Ezetimibe?
Taking these medicines together greatly increases the risk of serious muscle breakdown and damage.
Ezetimibe carries more major-labeled pairs than Cyclosporine
SPL source-record counts only. This page's band is major · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Ezetimibe (Cholesterol Absorption Inhibitor).
Ezetimibe has 8 major-labeled pairs vs Cyclosporine's 5.
5 major · 24 moderate · 60 minor · 89 total
- Other major peers for Cyclosporine
- Clarithromycin
- Ezetimibe/Simvastatin
- Pitavastatin
- Simvastatin
8 major · 4 moderate · 13 minor · 25 total
- Other major peers for Ezetimibe
- Amlodipine
- Diltiazem
- Verapamil
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.