Perindopril and Aliskiren Interaction
Drug interaction information between Perindopril and Aliskiren.
Perindopril and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Perindopril and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together puts too much stress on the system that controls blood pressure and kidney function. This can cause your blood pressure to drop too low and may lead to sudden kidney failure.
FDA Label Information
7.8 Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with perindopril erbumine in patients with diabetes. Avoid use of aliskiren with perindopril erbumine in patients with renal impairment (GFR <60 mL/min).
Perindopril Also Interacts With
- Spironolactone moderate
- Cyclosporine moderate
- Amiloride moderate
- Indomethacin moderate
- Heparin moderate
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Perindopril's 9. In the major band specifically: Perindopril has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Perindopril and Aliskiren?
Using these two drugs together puts too much stress on the system that controls blood pressure and kidney function. This can cause your blood pressure to drop too low and may lead to sudden kidney failure.
Aliskiren carries more major-labeled pairs than Perindopril
SPL source-record counts only. This page's band is major · classes on file: Perindopril (ACE Inhibitor); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Perindopril's 1.
1 major · 5 moderate · 3 minor · 9 total
Perindopril has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.