Cyclosporine and Aliskiren Interaction
Drug interaction information between Cyclosporine and Aliskiren.
Cyclosporine and Aliskiren have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cyclosporine and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine can cause aliskiren levels to rise significantly in your blood, which increases the risk of side effects.
FDA Label Information
7 DRUG INTERACTIONS Cyclosporine: Avoid coadministration of cyclosporine with aliskiren [see Warnings and Precautions ( 5.7 ) and Clinical Pharmacology ( 12.3 )] . Cyclosporine or Itraconazole: Avoid concomitant use.
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Aliskiren?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Aliskiren's 28. In the moderate band specifically: Cyclosporine has 24 (also Allopurinol, Amiloride, Amlodipine/Valsartan, Atorvastatin); Aliskiren has 3 (also Itraconazole, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Cyclosporine and Aliskiren?
Cyclosporine can cause aliskiren levels to rise significantly in your blood, which increases the risk of side effects.
Aliskiren carries more major-labeled pairs than Cyclosporine
SPL source-record counts only. This page's band is moderate · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Cyclosporine's 5. This page itself is in the moderate band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
- Atorvastatin
22 major · 3 moderate · 3 minor · 28 total
- Other moderate peers for Aliskiren
- Itraconazole
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.