Cyclosporine and Pitavastatin Interaction
Drug interaction information between Cyclosporine and Pitavastatin.
Cyclosporine and Pitavastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Cyclosporine and Pitavastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine stops the body from clearing pitavastatin, causing the medicine to build up to unsafe levels in the blood. This significantly increases the risk of serious muscle damage and kidney problems.
FDA Label Information
Drug Interactions that Increase the Risk of Myopathy and Rhabdomyolysis with pitavastatin tablets Cyclosporine Clinical Impact: Cyclosporine significantly increases pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis. Intervention: Concomitant use of cyclosporine with pitavastatin tablets is contraindicated [see Contraindications ( 4 )].
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Aliskiren moderate
Pitavastatin Also Interacts With
- Erythromycin major
- Rifampin major
- Colchicine moderate
- Gemfibrozil moderate
- Niacin moderate
Frequently Asked Questions
What SPL severity band is on file for Cyclosporine + Pitavastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Pitavastatin's 9. In the major band specifically: Cyclosporine has 5 (also Clarithromycin, Ezetimibe, Ezetimibe/Simvastatin, Simvastatin); Pitavastatin has 3 (also Erythromycin, Rifampin).
What mechanism field is on file for Cyclosporine and Pitavastatin?
Cyclosporine stops the body from clearing pitavastatin, causing the medicine to build up to unsafe levels in the blood. This significantly increases the risk of serious muscle damage and kidney problems.
Cyclosporine carries more major-labeled pairs than Pitavastatin
SPL source-record counts only. This page's band is major · classes on file: Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)); Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)).
Cyclosporine has 5 major-labeled pairs vs Pitavastatin's 3.
5 major · 24 moderate · 60 minor · 89 total
- Other major peers for Cyclosporine
- Clarithromycin
- Ezetimibe
- Ezetimibe/Simvastatin
- Simvastatin
3 major · 4 moderate · 2 minor · 9 total
- Other major peers for Pitavastatin
- Erythromycin
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.