Perindopril and Amiloride Interaction
Drug interaction information between Perindopril and Amiloride.
Perindopril and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Perindopril and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs prevent your kidneys from removing potassium, which can lead to a buildup in your system.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Indomethacin moderate
- Heparin moderate
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Amiloride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Perindopril's 9. In the moderate band specifically: Perindopril has 5 (also Spironolactone, Cyclosporine, Indomethacin, Heparin); Amiloride has 7 (also Cyclosporine, Lithium, Amlodipine/Benazepril, Benazepril).
What mechanism field is on file for Perindopril and Amiloride?
Both drugs prevent your kidneys from removing potassium, which can lead to a buildup in your system.
Amiloride's labeled portfolio outnumbers Perindopril
SPL source-record counts only. This page's band is moderate · classes on file: Perindopril (ACE Inhibitor); Amiloride (Potassium-Sparing Diuretic).
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Perindopril
- Spironolactone
- Cyclosporine
- Indomethacin
- Heparin
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Lithium
- Amlodipine/Benazepril
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.