Omeprazole and Carbamazepine Interaction
Drug interaction information between Omeprazole and Carbamazepine.
Omeprazole and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Omeprazole and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole can slow down how your body gets rid of carbamazepine, causing the medicine to reach higher levels in your blood.
FDA Label Information
Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors.
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Omeprazole + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Omeprazole's 27. In the minor band specifically: Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carisoprodol); Carbamazepine has 110 (also Ibuprofen, Citalopram, Amitriptyline, Acetaminophen).
What mechanism field is on file for Omeprazole and Carbamazepine?
Omeprazole can slow down how your body gets rid of carbamazepine, causing the medicine to reach higher levels in your blood.
Carbamazepine carries more major-labeled pairs than Omeprazole
SPL source-record counts only. This page's band is minor · classes on file: Omeprazole (Proton Pump Inhibitor (PPI)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Omeprazole's 1. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carisoprodol
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Ibuprofen
- Citalopram
- Amitriptyline
- Acetaminophen
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.