Omeprazole and Aripiprazole Interaction
Drug interaction information between Omeprazole and Aripiprazole.
Omeprazole and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Omeprazole and Aripiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aripiprazole does not change how your body processes omeprazole, so the levels of the medicine in your blood stay the same.
FDA Label Information
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Aripiprazole Also Interacts With
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
- Venlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Omeprazole + Aripiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Aripiprazole's 19. In the minor band specifically: Omeprazole has 22 (also Atomoxetine, Brexpiprazole, Carbamazepine, Carisoprodol); Aripiprazole has 19 (also Sertraline, Escitalopram, Fluoxetine, Famotidine).
What mechanism field is on file for Omeprazole and Aripiprazole?
Aripiprazole does not change how your body processes omeprazole, so the levels of the medicine in your blood stay the same.
Omeprazole carries more major-labeled pairs than Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Omeprazole (Proton Pump Inhibitor (PPI)); Aripiprazole (Atypical Antipsychotic).
Omeprazole has 1 major-labeled pair vs Aripiprazole's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
- Carisoprodol
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Sertraline
- Escitalopram
- Fluoxetine
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.