Omeprazole and Atomoxetine Interaction
Drug interaction information between Omeprazole and Atomoxetine.
Omeprazole and Atomoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Omeprazole and Atomoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole changes the acid levels in the stomach, but this does not change how the body absorbs atomoxetine.
FDA Label Information
7.9 Drugs that Affect Gastric pH Drugs that elevate gastric pH (magnesium hydroxide/aluminum hydroxide, omeprazole) had no effect on atomoxetine bioavailability.
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Atomoxetine Also Interacts With
- Albuterol moderate
- Fluoxetine minor
- Methylphenidate minor
- Warfarin minor
- Diazepam minor
Frequently Asked Questions
What SPL severity band is on file for Omeprazole + Atomoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Atomoxetine's 15. In the minor band specifically: Omeprazole has 22 (also Aripiprazole, Brexpiprazole, Carbamazepine, Carisoprodol); Atomoxetine has 14 (also Fluoxetine, Methylphenidate, Warfarin, Diazepam).
What mechanism field is on file for Omeprazole and Atomoxetine?
Omeprazole changes the acid levels in the stomach, but this does not change how the body absorbs atomoxetine.
Omeprazole carries more major-labeled pairs than Atomoxetine
SPL source-record counts only. This page's band is minor · classes on file: Omeprazole (Proton Pump Inhibitor (PPI)); Atomoxetine (Selective Norepinephrine Reuptake Inhibitor).
Omeprazole has 1 major-labeled pair vs Atomoxetine's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Brexpiprazole
- Carbamazepine
- Carisoprodol
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Atomoxetine
- Fluoxetine
- Methylphenidate
- Warfarin
- Diazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.