Omeprazole and Theophylline Interaction
Drug interaction information between Omeprazole and Theophylline.
Omeprazole and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Omeprazole and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole does not change how fast your body breaks down and gets rid of theophylline.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Omeprazole Also Interacts With
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Amoxicillin major
- Famotidine major
- Prednisone major
Frequently Asked Questions
What SPL severity band is on file for Omeprazole + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Omeprazole's 27. In the major band specifically: Omeprazole has 1; Theophylline has 27 (also Metoprolol, Albuterol, Amoxicillin, Famotidine).
What mechanism field is on file for Omeprazole and Theophylline?
Omeprazole does not change how fast your body breaks down and gets rid of theophylline.
Theophylline carries more major-labeled pairs than Omeprazole
SPL source-record counts only. This page's band is major · classes on file: Omeprazole (Proton Pump Inhibitor (PPI)); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Omeprazole's 1.
1 major · 4 moderate · 22 minor · 27 total
Omeprazole has no other major-band peer in this dataset besides Theophylline.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Amoxicillin
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.