Omeprazole and Theophylline Interaction
Drug interaction information between Omeprazole and Theophylline.
Omeprazole and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Omeprazole and Theophylline. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Omeprazole does not change how fast your body breaks down and gets rid of theophylline.
What To Do
You can usually take these two medicines together without changing your dose.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Omeprazole Also Interacts With
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Amoxicillin major
- Famotidine major
- Prednisone major
Frequently Asked Questions
Can I take Omeprazole and Theophylline together?
This is a major interaction. You can usually take these two medicines together without changing your dose.
How serious is the interaction between Omeprazole and Theophylline?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Omeprazole and Theophylline interact?
Omeprazole does not change how fast your body breaks down and gets rid of theophylline.
Understanding the Omeprazole and Theophylline Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Omeprazole belongs to the Proton Pump Inhibitor (PPI) class and Theophylline belongs to the Methylxanthine Bronchodilator class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Omeprazole does not change how fast your body breaks down and gets rid of theophylline. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Omeprazole has 27 total documented interactions on file in this dataset, and Theophylline has 86. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can usually take these two medicines together without changing your dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Omeprazole or Theophylline based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.