Omeprazole and Brexpiprazole Interaction
Drug interaction information between Omeprazole and Brexpiprazole.
Omeprazole and Brexpiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Omeprazole and Brexpiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole changes the acid levels in the stomach, but this does not affect how the body absorbs or processes brexpiprazole.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with REXULTI Based on pharmacokinetic studies, no dosage adjustment of REXULTI is required when administered concomitantly with CYP2B6 inhibitors (e.g., ticlopidine) or gastric pH modifiers (e.g., omeprazole).
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Brexpiprazole Also Interacts With
- Rosuvastatin minor
- Bupropion minor
- Fluoxetine minor
- Paroxetine minor
- Lovastatin minor
Frequently Asked Questions
What SPL severity band is on file for Omeprazole + Brexpiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Brexpiprazole's 9. In the minor band specifically: Omeprazole has 22 (also Aripiprazole, Atomoxetine, Carbamazepine, Carisoprodol); Brexpiprazole has 9 (also Rosuvastatin, Bupropion, Fluoxetine, Paroxetine).
What mechanism field is on file for Omeprazole and Brexpiprazole?
Omeprazole changes the acid levels in the stomach, but this does not affect how the body absorbs or processes brexpiprazole.
Omeprazole carries more major-labeled pairs than Brexpiprazole
SPL source-record counts only. This page's band is minor · classes on file: Omeprazole (Proton Pump Inhibitor (PPI)); Brexpiprazole (Atypical Antipsychotic).
Omeprazole has 1 major-labeled pair vs Brexpiprazole's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Carbamazepine
- Carisoprodol
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Brexpiprazole
- Rosuvastatin
- Bupropion
- Fluoxetine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.