Omeprazole and Darunavir Interaction
Drug interaction information between Omeprazole and Darunavir.
Omeprazole and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Omeprazole and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir can lower the amount of omeprazole in your body, making the stomach medicine less effective at treating acid. This happens because of how the drugs interact during processing in the body.
What To Do
Tell your doctor if your acid reflux symptoms get worse. They may increase your omeprazole dose, but you should not take more than 40 mg per day.
FDA Label Information
Proton pump inhibitor: omeprazole ↓ omeprazole ↔ darunavir When omeprazole is co-administered with darunavir/ritonavir, monitor patients for decreased efficacy of omeprazole. Consider increasing the omeprazole dose in patients whose symptoms are not well controlled; avoid use of more than 40 mg per day of omeprazole.
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Omeprazole and Darunavir together?
This is a moderate interaction. Tell your doctor if your acid reflux symptoms get worse. They may increase your omeprazole dose, but you should not take more than 40 mg per day.
How serious is the interaction between Omeprazole and Darunavir?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Omeprazole and Darunavir interact?
Darunavir can lower the amount of omeprazole in your body, making the stomach medicine less effective at treating acid. This happens because of how the drugs interact during processing in the body.
Understanding the Omeprazole and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Omeprazole belongs to the Proton Pump Inhibitor (PPI) class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir can lower the amount of omeprazole in your body, making the stomach medicine less effective at treating acid. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Omeprazole has 27 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Tell your doctor if your acid reflux symptoms get worse. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Omeprazole or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.