Omeprazole and Clopidogrel Interaction
Drug interaction information between Omeprazole and Clopidogrel.
Omeprazole and Clopidogrel have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Omeprazole and Clopidogrel. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Omeprazole stops clopidogrel from working correctly by preventing it from turning into its active form. This makes the medicine less effective at stopping blood clots.
What To Do
Avoid taking these two drugs together. Your doctor may suggest a different medicine for your stomach.
FDA Label Information
Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole. In clinical studies, omeprazole was shown to reduce significantly the antiplatelet activity of clopidogrel when given concomitantly or 12 hours apart. A similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with clopidogrel.
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Darunavir moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Clopidogrel Also Interacts With
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Omeprazole and Clopidogrel together?
This is a moderate interaction. Avoid taking these two drugs together. Your doctor may suggest a different medicine for your stomach.
How serious is the interaction between Omeprazole and Clopidogrel?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Omeprazole and Clopidogrel interact?
Omeprazole stops clopidogrel from working correctly by preventing it from turning into its active form. This makes the medicine less effective at stopping blood clots.
Understanding the Omeprazole and Clopidogrel Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Omeprazole belongs to the Proton Pump Inhibitor (PPI) class and Clopidogrel belongs to the Antiplatelet Agent class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Omeprazole stops clopidogrel from working correctly by preventing it from turning into its active form. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Omeprazole has 27 total documented interactions on file in this dataset, and Clopidogrel has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking these two drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Omeprazole or Clopidogrel based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.