Omeprazole and Clopidogrel Interaction
Drug interaction information between Omeprazole and Clopidogrel.
Omeprazole and Clopidogrel have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Omeprazole and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole stops clopidogrel from working correctly by preventing it from turning into its active form. This makes the medicine less effective at stopping blood clots.
FDA Label Information
Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole. In clinical studies, omeprazole was shown to reduce significantly the antiplatelet activity of clopidogrel when given concomitantly or 12 hours apart. A similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with clopidogrel.
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Darunavir moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Clopidogrel Also Interacts With
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Omeprazole + Clopidogrel?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Clopidogrel's 19. In the moderate band specifically: Omeprazole has 4 (also Clarithromycin, Darunavir, Tacrolimus Topical); Clopidogrel has 9 (also Warfarin, Esomeprazole, Rifampin, Norepinephrine).
What mechanism field is on file for Omeprazole and Clopidogrel?
Omeprazole stops clopidogrel from working correctly by preventing it from turning into its active form. This makes the medicine less effective at stopping blood clots.
Omeprazole carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is moderate · classes on file: Omeprazole (Proton Pump Inhibitor (PPI)); Clopidogrel (Antiplatelet Agent).
Omeprazole has 1 major-labeled pair vs Clopidogrel's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 22 minor · 27 total
- Other moderate peers for Omeprazole
- Clarithromycin
- Darunavir
- Tacrolimus Topical
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Warfarin
- Esomeprazole
- Rifampin
- Norepinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.