Nebivolol and Paroxetine Interaction
Drug interaction information between Nebivolol and Paroxetine.
Nebivolol and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nebivolol and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine blocks the enzyme that helps your body get rid of nebivolol. This can cause the levels of this blood pressure medicine to rise in your system.
FDA Label Information
Examples propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone.
Nebivolol Also Interacts With
- Fluoxetine moderate
- Propafenone moderate
- Clonidine minor
- Diltiazem minor
- Verapamil minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Nebivolol + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Nebivolol's 7. In the minor band specifically: Nebivolol has 5 (also Clonidine, Diltiazem, Verapamil, Desvenlafaxine); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Nebivolol and Paroxetine?
Paroxetine blocks the enzyme that helps your body get rid of nebivolol. This can cause the levels of this blood pressure medicine to rise in your system.
Paroxetine carries more major-labeled pairs than Nebivolol
SPL source-record counts only. This page's band is minor · classes on file: Nebivolol (Beta-1 Selective Blocker); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Nebivolol's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Nebivolol
- Clonidine
- Diltiazem
- Verapamil
- Desvenlafaxine
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.