Nebivolol and Diltiazem Interaction
Drug interaction information between Nebivolol and Diltiazem.
Nebivolol and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nebivolol and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines slow the heart rate and lower blood pressure. Using them together can cause your heart to beat too slowly or weaken its pumping strength.
FDA Label Information
( 7.3 ) Verapamil- or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate, blood pressure, and cardiac contractility. 7.4 Calcium Channel Blockers Nebivolol can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide.
Nebivolol Also Interacts With
- Fluoxetine moderate
- Propafenone moderate
- Clonidine minor
- Verapamil minor
- Desvenlafaxine minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Nebivolol + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Nebivolol's 7. In the minor band specifically: Nebivolol has 5 (also Clonidine, Verapamil, Desvenlafaxine, Paroxetine); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Nebivolol and Diltiazem?
Both of these medicines slow the heart rate and lower blood pressure. Using them together can cause your heart to beat too slowly or weaken its pumping strength.
Diltiazem carries more major-labeled pairs than Nebivolol
SPL source-record counts only. This page's band is minor · classes on file: Nebivolol (Beta-1 Selective Blocker); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Nebivolol's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Nebivolol
- Clonidine
- Verapamil
- Desvenlafaxine
- Paroxetine
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.