Nebivolol and Propafenone Interaction
Drug interaction information between Nebivolol and Propafenone.
Nebivolol and Propafenone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nebivolol and Propafenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Propafenone slows down the body's ability to process nebivolol, which could cause the medication to build up to higher levels.
FDA Label Information
( 7.4 ) 7.1 CYP2D6 Inhibitors Use caution when nebivolol is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.) [ see Clinical Pharmacology ( 12.5 ) ].
Nebivolol Also Interacts With
- Fluoxetine moderate
- Clonidine minor
- Diltiazem minor
- Verapamil minor
- Desvenlafaxine minor
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Amiodarone moderate
- Fluoxetine moderate
- Ketoconazole minor
- Erythromycin minor
Frequently Asked Questions
What SPL severity band is on file for Nebivolol + Propafenone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propafenone has 26 labeled pairs on file vs Nebivolol's 7. In the moderate band specifically: Nebivolol has 2 (also Fluoxetine); Propafenone has 3 (also Amiodarone, Fluoxetine).
What mechanism field is on file for Nebivolol and Propafenone?
Propafenone slows down the body's ability to process nebivolol, which could cause the medication to build up to higher levels.
Propafenone carries more major-labeled pairs than Nebivolol
SPL source-record counts only. This page's band is moderate · classes on file: Nebivolol (Beta-1 Selective Blocker); Propafenone (Class IC Antiarrhythmic).
Propafenone has 1 major-labeled pair vs Nebivolol's 0. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other moderate peers for Propafenone
- Amiodarone
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.