What the FDA labels say about taking them together
Nebivolol and propafenone
Nebivolol's FDA label of August 1, 2024 names propafenone in its drug interactions section; propafenone's label does not name nebivolol itself but warns about its class (Beta blockers).
Check it at the source: the nebivolol FDA label on DailyMed (effective August 1, 2024, Allergan, Inc.); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the nebivolol label say about propafenone?
Nebivolol label, drug interactionsUse caution when BYSTOLIC is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.) [see Clinical Pharmacology ( 12.5 )].
Source: FDA drug label (Bystolic), Allergan, Inc., effective August 1, 2024 (SPL set 8b8ad213-1dc8-454e-a524-075685c0e1a8), via openFDA; the full label on DailyMed
What does the propafenone label say about nebivolol?
Propafenone's label does not name nebivolol itself; it warns about its class (Beta blockers):
Propafenone label, drug interactionsIn clinical trials using propafenone immediate release tablets, subjects who were receiving beta-blockers concurrently did not experience an increased incidence of side effects.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nebivolol | Propafenone | |
|---|---|---|
| Labeled for | High blood pressure | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.141 per tablet 10 mg tablet | $0.115 per tablet 150 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once