Nebivolol and Clonidine Interaction
Drug interaction information between Nebivolol and Clonidine.
Nebivolol and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nebivolol and Clonidine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs work to slow down the body's nervous system activity. Taking them together can cause an safely large drop in this activity.
What To Do
If you need to stop these medicines, your doctor should have you stop nebivolol several days before slowly lowering your clonidine dose.
FDA Label Information
7 DRUG INTERACTIONS CYP2D6 enzyme inhibitors may increase nebivolol levels ( 7.1 ) Reserpine or clonidine may produce excessive reduction of sympathetic activity. In patients who are receiving nebivolol and clonidine, discontinue nebivolol tablets for several days before the gradual tapering of clonidine.
Nebivolol Also Interacts With
- Fluoxetine moderate
- Propafenone moderate
- Diltiazem minor
- Verapamil minor
- Desvenlafaxine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
Can I take Nebivolol and Clonidine together?
This is a minor interaction. If you need to stop these medicines, your doctor should have you stop nebivolol several days before slowly lowering your clonidine dose.
How serious is the interaction between Nebivolol and Clonidine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Nebivolol and Clonidine interact?
Both drugs work to slow down the body's nervous system activity. Taking them together can cause an safely large drop in this activity.
Understanding the Nebivolol and Clonidine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Nebivolol belongs to the Beta-1 Selective Blocker class and Clonidine belongs to the Central Alpha-2 Agonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs work to slow down the body's nervous system activity. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Nebivolol has 7 total documented interactions on file in this dataset, and Clonidine has 29. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: If you need to stop these medicines, your doctor should have you stop nebivolol several days before slowly lowering your clonidine dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Nebivolol or Clonidine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.