Nebivolol and Clonidine Interaction
Drug interaction information between Nebivolol and Clonidine.
Nebivolol and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nebivolol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work to slow down the body's nervous system activity. Taking them together can cause an safely large drop in this activity.
FDA Label Information
7 DRUG INTERACTIONS CYP2D6 enzyme inhibitors may increase nebivolol levels ( 7.1 ) Reserpine or clonidine may produce excessive reduction of sympathetic activity. In patients who are receiving nebivolol and clonidine, discontinue nebivolol tablets for several days before the gradual tapering of clonidine.
Nebivolol Also Interacts With
- Fluoxetine moderate
- Propafenone moderate
- Diltiazem minor
- Verapamil minor
- Desvenlafaxine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Nebivolol + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Nebivolol's 7. In the minor band specifically: Nebivolol has 5 (also Diltiazem, Verapamil, Desvenlafaxine, Paroxetine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Nebivolol and Clonidine?
Both drugs work to slow down the body's nervous system activity. Taking them together can cause an safely large drop in this activity.
Clonidine's labeled portfolio outnumbers Nebivolol
SPL source-record counts only. This page's band is minor · classes on file: Nebivolol (Beta-1 Selective Blocker); Clonidine (Central Alpha-2 Agonist).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Nebivolol
- Diltiazem
- Verapamil
- Desvenlafaxine
- Paroxetine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.