Nebivolol and Fluoxetine Interaction
Drug interaction information between Nebivolol and Fluoxetine.
Nebivolol and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nebivolol and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine blocks the liver protein responsible for breaking down nebivolol, which can lead to higher levels of the drug in your blood.
FDA Label Information
( 7.4 ) 7.1 CYP2D6 Inhibitors Use caution when nebivolol is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.) [ see Clinical Pharmacology ( 12.5 ) ].
Nebivolol Also Interacts With
- Propafenone moderate
- Clonidine minor
- Diltiazem minor
- Verapamil minor
- Desvenlafaxine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Nebivolol + Fluoxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Nebivolol's 7. In the moderate band specifically: Nebivolol has 2 (also Propafenone); Fluoxetine has 19 (also Alprazolam, Diazepam, Carbamazepine, Haloperidol).
What mechanism field is on file for Nebivolol and Fluoxetine?
Fluoxetine blocks the liver protein responsible for breaking down nebivolol, which can lead to higher levels of the drug in your blood.
Fluoxetine carries more major-labeled pairs than Nebivolol
SPL source-record counts only. This page's band is moderate · classes on file: Nebivolol (Beta-1 Selective Blocker); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Nebivolol's 0. This page itself is in the moderate band, not the major band.
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Diazepam
- Carbamazepine
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.