Nebivolol and Verapamil Interaction
Drug interaction information between Nebivolol and Verapamil.
Nebivolol and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nebivolol and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both act on the heart to slow it down and lower blood pressure. Combining them can cause your heart rate or blood pressure to drop to levels that are too low.
FDA Label Information
( 7.3 ) Verapamil- or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate, blood pressure, and cardiac contractility. 7.4 Calcium Channel Blockers Nebivolol can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide.
Nebivolol Also Interacts With
- Fluoxetine moderate
- Propafenone moderate
- Clonidine minor
- Diltiazem minor
- Desvenlafaxine minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Nebivolol + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Nebivolol's 7. In the minor band specifically: Nebivolol has 5 (also Clonidine, Diltiazem, Desvenlafaxine, Paroxetine); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Nebivolol and Verapamil?
These drugs both act on the heart to slow it down and lower blood pressure. Combining them can cause your heart rate or blood pressure to drop to levels that are too low.
Verapamil carries more major-labeled pairs than Nebivolol
SPL source-record counts only. This page's band is minor · classes on file: Nebivolol (Beta-1 Selective Blocker); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Nebivolol's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Nebivolol
- Clonidine
- Diltiazem
- Desvenlafaxine
- Paroxetine
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.