Nebivolol and Desvenlafaxine Interaction
Drug interaction information between Nebivolol and Desvenlafaxine.
Nebivolol and Desvenlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nebivolol and Desvenlafaxine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Desvenlafaxine can slightly slow down how your liver processes nebivolol, which may cause the drug to stay in your system longer.
What To Do
No dose changes are usually needed, but you should tell your doctor if you notice any new or unusual side effects.
FDA Label Information
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Nebivolol Also Interacts With
- Fluoxetine moderate
- Propafenone moderate
- Clonidine minor
- Diltiazem minor
- Verapamil minor
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
Can I take Nebivolol and Desvenlafaxine together?
This is a minor interaction. No dose changes are usually needed, but you should tell your doctor if you notice any new or unusual side effects.
How serious is the interaction between Nebivolol and Desvenlafaxine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Nebivolol and Desvenlafaxine interact?
Desvenlafaxine can slightly slow down how your liver processes nebivolol, which may cause the drug to stay in your system longer.
Understanding the Nebivolol and Desvenlafaxine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Nebivolol belongs to the Beta-1 Selective Blocker class and Desvenlafaxine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Desvenlafaxine can slightly slow down how your liver processes nebivolol, which may cause the drug to stay in your system longer. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Nebivolol has 7 total documented interactions on file in this dataset, and Desvenlafaxine has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dose changes are usually needed, but you should tell your doctor if you notice any new or unusual side effects. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Nebivolol or Desvenlafaxine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.