Misoprostol and Furosemide Interaction
Drug interaction information between Misoprostol and Furosemide.
Misoprostol and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Misoprostol and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can prevent your water pill from working correctly, making it harder for your body to get rid of extra salt and fluid.
FDA Label Information
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients.
Misoprostol Also Interacts With
- Diclofenac moderate
- Methotrexate moderate
- Diflunisal moderate
- Aspirin minor
- Propranolol minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Misoprostol + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Misoprostol's 12. In the minor band specifically: Misoprostol has 9 (also Aspirin, Propranolol, Warfarin, Cyclosporine); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Misoprostol and Furosemide?
This combination can prevent your water pill from working correctly, making it harder for your body to get rid of extra salt and fluid.
Furosemide carries more major-labeled pairs than Misoprostol
SPL source-record counts only. This page's band is minor · classes on file: Misoprostol (Prostaglandin E1 Analog); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Misoprostol's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Misoprostol
- Aspirin
- Propranolol
- Warfarin
- Cyclosporine
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.