Misoprostol and Warfarin Interaction
Drug interaction information between Misoprostol and Warfarin.
Misoprostol and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Misoprostol and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs interfere with how your blood clots, which makes bleeding more likely when they are used at the same time.
Misoprostol Also Interacts With
- Diclofenac moderate
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Misoprostol + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Misoprostol's 12. In the minor band specifically: Misoprostol has 9 (also Furosemide, Aspirin, Propranolol, Cyclosporine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Misoprostol and Warfarin?
Both drugs interfere with how your blood clots, which makes bleeding more likely when they are used at the same time.
Warfarin carries more major-labeled pairs than Misoprostol
SPL source-record counts only. This page's band is minor · classes on file: Misoprostol (Prostaglandin E1 Analog); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Misoprostol's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Misoprostol
- Furosemide
- Aspirin
- Propranolol
- Cyclosporine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.