Misoprostol and Diflunisal Interaction
Drug interaction information between Misoprostol and Diflunisal.
Misoprostol and Diflunisal have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Misoprostol and Diflunisal. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together increases the risk of stomach and intestinal damage without providing extra benefits. Both drugs belong to a class that can irritate the digestive tract.
FDA Label Information
NSAIDs and Salicylates Clinical Impact: Concomitant use of diclofenac with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [see Warnings and Precautions (5.3) ].
Misoprostol Also Interacts With
- Diclofenac moderate
- Methotrexate moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Celecoxib moderate
- Indomethacin moderate
- Mefenamic Acid moderate
Frequently Asked Questions
What SPL severity band is on file for Misoprostol + Diflunisal?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diflunisal has 17 labeled pairs on file vs Misoprostol's 12. In the moderate band specifically: Misoprostol has 3 (also Diclofenac, Methotrexate); Diflunisal has 11 (also Methotrexate, Cyclosporine, Celecoxib, Indomethacin).
What mechanism field is on file for Misoprostol and Diflunisal?
Taking these two drugs together increases the risk of stomach and intestinal damage without providing extra benefits. Both drugs belong to a class that can irritate the digestive tract.
Diflunisal's labeled portfolio outnumbers Misoprostol
SPL source-record counts only. This page's band is moderate · classes on file: Misoprostol (Prostaglandin E1 Analog); Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 3 moderate · 9 minor · 12 total
- Other moderate peers for Misoprostol
- Diclofenac
- Methotrexate
0 major · 11 moderate · 6 minor · 17 total
- Other moderate peers for Diflunisal
- Methotrexate
- Cyclosporine
- Celecoxib
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.