Misoprostol and Aspirin Interaction
Drug interaction information between Misoprostol and Aspirin.
Misoprostol and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Misoprostol and Aspirin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these two drugs together increases the chance of serious stomach bleeding and does not provide any extra pain relief.
What To Do
Tell your doctor if you notice signs of bleeding, like dark stools, or if you have new stomach pain.
FDA Label Information
Intervention: Monitor patients with concomitant use of diclofenac sodium/misoprostol with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [see Warnings and Precautions (5.12) ] . Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as...
Misoprostol Also Interacts With
- Diclofenac moderate
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Propranolol minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Misoprostol and Aspirin together?
This is a minor interaction. Tell your doctor if you notice signs of bleeding, like dark stools, or if you have new stomach pain.
How serious is the interaction between Misoprostol and Aspirin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Misoprostol and Aspirin interact?
Taking these two drugs together increases the chance of serious stomach bleeding and does not provide any extra pain relief.
Understanding the Misoprostol and Aspirin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Misoprostol belongs to the Prostaglandin E1 Analog class and Aspirin belongs to the Antiplatelet / NSAID class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these two drugs together increases the chance of serious stomach bleeding and does not provide any extra pain relief. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Misoprostol has 12 total documented interactions on file in this dataset, and Aspirin has 47. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Tell your doctor if you notice signs of bleeding, like dark stools, or if you have new stomach pain. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Misoprostol or Aspirin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.