Misoprostol and Propranolol Interaction
Drug interaction information between Misoprostol and Propranolol.
Misoprostol and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Misoprostol and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine can make your blood pressure drug less effective, which may cause your blood pressure to go up.
FDA Label Information
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of ACE inhibitors, ARBs, or beta-blockers (including propranolol).
Misoprostol Also Interacts With
- Diclofenac moderate
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Misoprostol + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Misoprostol's 12. In the minor band specifically: Misoprostol has 9 (also Furosemide, Aspirin, Warfarin, Cyclosporine); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Misoprostol and Propranolol?
This medicine can make your blood pressure drug less effective, which may cause your blood pressure to go up.
Propranolol's labeled portfolio outnumbers Misoprostol
SPL source-record counts only. This page's band is minor · classes on file: Misoprostol (Prostaglandin E1 Analog); Propranolol (Non-Selective Beta-Blocker).
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Misoprostol
- Furosemide
- Aspirin
- Warfarin
- Cyclosporine
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.