Misoprostol and Cyclosporine Interaction
Drug interaction information between Misoprostol and Cyclosporine.
Misoprostol and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Misoprostol and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can increase the risk of harm to your kidneys.
FDA Label Information
Cyclosporine Clinical Impact: Concomitant use of diclofenac and cyclosporine may increase cyclosporine's nephrotoxicity. Intervention: During concomitant use of diclofenac sodium/misoprostol and cyclosporine, monitor patients for signs of worsening renal function.
Misoprostol Also Interacts With
- Diclofenac moderate
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Misoprostol + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Misoprostol's 12. In the minor band specifically: Misoprostol has 9 (also Furosemide, Aspirin, Propranolol, Warfarin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Misoprostol and Cyclosporine?
Using these drugs together can increase the risk of harm to your kidneys.
Cyclosporine carries more major-labeled pairs than Misoprostol
SPL source-record counts only. This page's band is minor · classes on file: Misoprostol (Prostaglandin E1 Analog); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Misoprostol's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Misoprostol
- Furosemide
- Aspirin
- Propranolol
- Warfarin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.