Midazolam and Diazepam Interaction
Drug interaction information between Midazolam and Diazepam.
Midazolam and Diazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Midazolam and Diazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There are no known harmful interactions between these two drugs when they are used together for medical procedures.
FDA Label Information
No significant adverse interactions with commonly used premedications or drugs used during anesthesia and surgery (including atropine, scopolamine, glycopyrrolate, diazepam, hydroxyzine, d-tubocurarine, succinylcholine and other nondepolarizing muscle relaxants) or topical local anesthetics (including lidocaine, dyclonine HCl and Cetacaine) have been observed in adults or pediatric patients.
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Diazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Diazepam's 26. In the minor band specifically: Midazolam has 27 (also Hydroxyzine, Nifedipine, Morphine, Atropine); Diazepam has 22 (also Omeprazole, Ketoconazole, Fluvoxamine, Cimetidine).
What mechanism field is on file for Midazolam and Diazepam?
There are no known harmful interactions between these two drugs when they are used together for medical procedures.
Midazolam carries more major-labeled pairs than Diazepam
SPL source-record counts only. This page's band is minor · classes on file: Midazolam (Benzodiazepine); Diazepam (Benzodiazepine).
Midazolam has 3 major-labeled pairs vs Diazepam's 0. This page itself is in the minor band, not the major band.
3 major · 9 moderate · 27 minor · 39 total
- Other minor peers for Midazolam
- Hydroxyzine
- Nifedipine
- Morphine
- Atropine
0 major · 4 moderate · 22 minor · 26 total
- Other minor peers for Diazepam
- Omeprazole
- Ketoconazole
- Fluvoxamine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.