Diazepam and Fluoxetine Interaction
Drug interaction information between Diazepam and Fluoxetine.
Diazepam and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diazepam and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine makes diazepam stay in your body for a longer time than usual. This can lead to a buildup of the drug and cause more side effects.
FDA Label Information
Monoamine Oxidase Inhibitors (MAOIs): ( 2.9 , 2.10 , 4.1 , 5.2 ) Drugs Metabolized by CYP2D6: Fluoxetine is a potent inhibitor of CYP2D6 enzyme pathway ( 7.7 ) Tricyclic Antidepressants (TCAs): Monitor TCA levels during coadministration with fluoxetine or when fluoxetine has been recently discontinued ( 5.2 , 7.7 ) CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs ( 7.2 ) Benzodiazepines: Diazepam – increased t½, alprazolam - further psychomotor performance decrement due to increased levels ( 7.7 ) Antipsychotics: Potential for elevation...
Diazepam Also Interacts With
- Clonazepam moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
- Ketoconazole minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Diazepam + Fluoxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Diazepam's 26. In the moderate band specifically: Diazepam has 4 (also Clonazepam, Mirtazapine, Raloxifene); Fluoxetine has 19 (also Alprazolam, Carbamazepine, Haloperidol, Clozapine).
What mechanism field is on file for Diazepam and Fluoxetine?
Fluoxetine makes diazepam stay in your body for a longer time than usual. This can lead to a buildup of the drug and cause more side effects.
Fluoxetine carries more major-labeled pairs than Diazepam
SPL source-record counts only. This page's band is moderate · classes on file: Diazepam (Benzodiazepine); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Diazepam's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 22 minor · 26 total
- Other moderate peers for Diazepam
- Clonazepam
- Mirtazapine
- Raloxifene
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Carbamazepine
- Haloperidol
- Clozapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.