Diazepam and Ketoconazole Interaction
Drug interaction information between Diazepam and Ketoconazole.
Diazepam and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diazepam and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole stops the body from breaking down diazepam normally. This can cause diazepam to build up in your system.
FDA Label Information
At present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole.
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Diazepam + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Diazepam's 26. In the minor band specifically: Diazepam has 22 (also Omeprazole, Fluvoxamine, Cimetidine, Phenytoin); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Diazepam and Ketoconazole?
Ketoconazole stops the body from breaking down diazepam normally. This can cause diazepam to build up in your system.
Ketoconazole carries more major-labeled pairs than Diazepam
SPL source-record counts only. This page's band is minor · classes on file: Diazepam (Benzodiazepine); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Diazepam's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 22 minor · 26 total
- Other minor peers for Diazepam
- Omeprazole
- Fluvoxamine
- Cimetidine
- Phenytoin
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.