Midazolam and Itraconazole Interaction
Drug interaction information between Midazolam and Itraconazole.
Midazolam and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Midazolam and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the breakdown of midazolam, making its calming effects much stronger and potentially dangerous.
FDA Label Information
Antipsychotics, Anxiolytics and Hypnotics Alprazolam a Midazolam (IV) a Aripiprazole a Quetiapine Buspirone a Cariprazine Ramelteon Diazepam a Risperidone a Haloperidol a Suvorexant Monitor for adverse reactions. Lurasidone Midazolam (oral) a Pimozide Triazolam a Contraindicated during and 2 weeks after itraconazole treatment.
Midazolam Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
- Erythromycin moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Felodipine major
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Midazolam's 39. In the major band specifically: Midazolam has 3 (also Darunavir, Nirmatrelvir/Ritonavir); Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone).
What mechanism field is on file for Midazolam and Itraconazole?
Itraconazole blocks the breakdown of midazolam, making its calming effects much stronger and potentially dangerous.
Itraconazole carries more major-labeled pairs than Midazolam
SPL source-record counts only. This page's band is major · classes on file: Midazolam (Benzodiazepine); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Midazolam's 3.
3 major · 9 moderate · 27 minor · 39 total
- Other major peers for Midazolam
- Darunavir
- Nirmatrelvir/Ritonavir
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.