Midazolam and Morphine Interaction
Drug interaction information between Midazolam and Morphine.
Midazolam and Morphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Midazolam and Morphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the central nervous system, which makes the sleepy and calming effects much stronger when they are used together.
FDA Label Information
Other CNS Depressants The sedative effect of intravenous midazolam is accentuated by any concomitantly administered medication, which depresses the central nervous system, particularly narcotics (e.g., morphine, meperidine and fentanyl) and also secobarbital and droperidol.
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Morphine Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Morphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Morphine's 30. In the minor band specifically: Midazolam has 27 (also Hydroxyzine, Nifedipine, Diazepam, Atropine); Morphine has 30 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine).
What mechanism field is on file for Midazolam and Morphine?
Both drugs slow down the central nervous system, which makes the sleepy and calming effects much stronger when they are used together.
Midazolam carries more major-labeled pairs than Morphine
SPL source-record counts only. This page's band is minor · classes on file: Midazolam (Benzodiazepine); Morphine (Opioid Analgesic).
Midazolam has 3 major-labeled pairs vs Morphine's 0. This page itself is in the minor band, not the major band.
3 major · 9 moderate · 27 minor · 39 total
- Other minor peers for Midazolam
- Hydroxyzine
- Nifedipine
- Diazepam
- Atropine
0 major · 0 moderate · 30 minor · 30 total
- Other minor peers for Morphine
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.