Diazepam and Clonazepam Interaction
Drug interaction information between Diazepam and Clonazepam.
Diazepam and Clonazepam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diazepam and Clonazepam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs are both sedatives that slow down your brain and body. Taking them together can make you dangerously sleepy or cause trouble breathing.
What To Do
Do not take these two medicines at the same time unless your doctor tells you to.
FDA Label Information
Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.
Diazepam Also Interacts With
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
- Ketoconazole minor
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Lamotrigine minor
- Fluconazole minor
Frequently Asked Questions
Can I take Diazepam and Clonazepam together?
This is a moderate interaction. Do not take these two medicines at the same time unless your doctor tells you to.
How serious is the interaction between Diazepam and Clonazepam?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Diazepam and Clonazepam interact?
These drugs are both sedatives that slow down your brain and body. Taking them together can make you dangerously sleepy or cause trouble breathing.
Understanding the Diazepam and Clonazepam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Diazepam belongs to the Benzodiazepine class and Clonazepam belongs to the Benzodiazepine class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs are both sedatives that slow down your brain and body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Diazepam has 26 total documented interactions on file in this dataset, and Clonazepam has 14. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these two medicines at the same time unless your doctor tells you to. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Diazepam or Clonazepam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.