Midazolam and Darunavir Interaction
Drug interaction information between Midazolam and Darunavir.
Midazolam and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Midazolam and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir blocks the enzyme that breaks down midazolam, causing the sedative to build up in your body. This can lead to dangerously deep sleep or breathing problems.
FDA Label Information
Sedatives/hypnotics: orally administered midazolam, triazolam ↑ midazolam ↑ triazolam Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as prolonged or increased sedation or respiratory depression. Triazolam and orally administered midazolam are extensively metabolized by CYP3A. Co-administration of triazolam or orally administered midazolam with darunavir may cause large increases in the concentrations of these benzodiazepines.
Midazolam Also Interacts With
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
- Erythromycin moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Midazolam's 39. In the major band specifically: Midazolam has 3 (also Itraconazole, Nirmatrelvir/Ritonavir); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Midazolam and Darunavir?
Darunavir blocks the enzyme that breaks down midazolam, causing the sedative to build up in your body. This can lead to dangerously deep sleep or breathing problems.
Darunavir carries more major-labeled pairs than Midazolam
SPL source-record counts only. This page's band is major · classes on file: Midazolam (Benzodiazepine); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Midazolam's 3.
3 major · 9 moderate · 27 minor · 39 total
- Other major peers for Midazolam
- Itraconazole
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.