Midazolam and Nifedipine Interaction
Drug interaction information between Midazolam and Nifedipine.
Midazolam and Nifedipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Midazolam and Nifedipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines do not interfere with each other when they are taken together.
FDA Label Information
No interaction was observed in healthy subjects between midazolam and nifedipine.
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Midazolam + Nifedipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Nifedipine's 26. In the minor band specifically: Midazolam has 27 (also Hydroxyzine, Morphine, Diazepam, Atropine); Nifedipine has 22 (also Fluoxetine, Fluconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Midazolam and Nifedipine?
These medicines do not interfere with each other when they are taken together.
Midazolam carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is minor · classes on file: Midazolam (Benzodiazepine); Nifedipine (Calcium Channel Blocker).
Midazolam has 3 major-labeled pairs vs Nifedipine's 1. This page itself is in the minor band, not the major band.
3 major · 9 moderate · 27 minor · 39 total
- Other minor peers for Midazolam
- Hydroxyzine
- Morphine
- Diazepam
- Atropine
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Nifedipine
- Fluoxetine
- Fluconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.