Diazepam and Fluvoxamine Interaction
Drug interaction information between Diazepam and Fluvoxamine.
Diazepam and Fluvoxamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diazepam and Fluvoxamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine blocks the enzymes that usually clear diazepam from your blood. This makes the effects of diazepam last longer and feel stronger.
FDA Label Information
At present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole.
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
Frequently Asked Questions
What SPL severity band is on file for Diazepam + Fluvoxamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Diazepam's 26. In the minor band specifically: Diazepam has 22 (also Omeprazole, Ketoconazole, Cimetidine, Phenytoin); Fluvoxamine has 36 (also Metoprolol, Omeprazole, Fluoxetine, Aspirin).
What mechanism field is on file for Diazepam and Fluvoxamine?
Fluvoxamine blocks the enzymes that usually clear diazepam from your blood. This makes the effects of diazepam last longer and feel stronger.
Fluvoxamine carries more major-labeled pairs than Diazepam
SPL source-record counts only. This page's band is minor · classes on file: Diazepam (Benzodiazepine); Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluvoxamine has 1 major-labeled pair vs Diazepam's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 22 minor · 26 total
- Other minor peers for Diazepam
- Omeprazole
- Ketoconazole
- Cimetidine
- Phenytoin
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Metoprolol
- Omeprazole
- Fluoxetine
- Aspirin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.