Diazepam and Cimetidine Interaction
Drug interaction information between Diazepam and Cimetidine.
Diazepam and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diazepam and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine interferes with how your liver handles diazepam. This results in higher amounts of diazepam staying in your body for a longer time.
FDA Label Information
At present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole.
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Diazepam + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Diazepam's 26. In the minor band specifically: Diazepam has 22 (also Omeprazole, Ketoconazole, Fluvoxamine, Phenytoin); Cimetidine has 63 (also Albendazole, Alogliptin, Alosetron, Alprazolam).
What mechanism field is on file for Diazepam and Cimetidine?
Cimetidine interferes with how your liver handles diazepam. This results in higher amounts of diazepam staying in your body for a longer time.
Cimetidine carries more major-labeled pairs than Diazepam
SPL source-record counts only. This page's band is minor · classes on file: Diazepam (Benzodiazepine); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Diazepam's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 22 minor · 26 total
- Other minor peers for Diazepam
- Omeprazole
- Ketoconazole
- Fluvoxamine
- Phenytoin
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alosetron
- Alprazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.